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Home » Asthma » Terbutaline Sulfate
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Terbutaline Sulfate
Generic name: Terbutaline Sulfate
Brand names: Brethine, Bricanyl, or Brethaire
Manufacturer: Various
Properties:
Adrenergic agonist which predominantly stimulates beta2-receptors, thus producing relaxation of bronchial smooth muscle. The effect has a duration of up to 8 hours.
Indications:
Bronchial asthma. Chronic bronchitis, emphysema and other lung diseases where bronchospasm is a complicating factor. Pre-term labor.
Contraindications:
Hypersensitivity to any of the ingredients.
Dosage:
Terbutaline Sulfate/Bricanyl tablets should be used as maintenance therapy. Dosage is individual.
Bronchospasm:
Adults: In general, the recommended dose during the first 1–2 weeks is, one tablet (2.5 mg) three times a day. May be increased to 2 tablets, three times a day.
Children: 0.075 mg/kg body weight, three times a day.
Pre-term labor: The drug must be individually titrated. Initial treatment is an infusion of Bricanyl solution for injection followed by oral maintenance therapy with Terbutaline Sulfate/Bricanyl tablets.
Warnings and Precautions:
Caution in patients with thyrotoxicosis and severe cardiovascular disorder. Additional blood glucose controls are recommended initially in diabetics. The hypokalemic effect of beta2-agonists may be potentiated by concomitant treatments (see Interactions). Particular caution is recommended in acute severe asthma. Serum potassium levels should be monitored in those situations.
Pregnancy and lactation:
As with other drugs administered during pregnancy, the benefits for the mother should be weighed against the risks for the fetus.
Undesirable effects:
Tremor, headache, tonic muscle cramps, and palpitations have been recorded. Tolerance to these effects usually develops within 1–2 weeks. Urticaria and exanthema may occur. Sleep and behavioral disturbances have been observed.
Interactions:
The effect of beta-agonists may be inhibited by beta-receptor blocking agents (especially those which are non-selective). Concomitant treatment with xanthines, steroids, or diuretics may potentiate hypokalemia.
This drug is shipped in blisters.
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