Pharmacology and use:
Chlorpropamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Chlorpropamide is twice as potent as the related second-generation agent glipizide. For managing hyperglycemia in Non-insulin-dependent diabetes mellitus (NIDDM).
Mechanism Of Action:
Sulfonylureas such as Chlorpropamide likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.
It may be used alone or with other antidiabetic medicines.
This drug is shipped in blisters.
More Chlorpropamide information
News Update
March 29, 2016:
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