Bupropion Dosage: What You Need to Know

Whether you’re starting bupropion for depression or to quit smoking, getting the dose right matters. Too low and you won’t feel the benefit; too high and side effects can creep in. Below we break down the common dosing schedules, how doctors adjust them, and practical tips to keep you on track.

Standard Dosage for Depression

For most adults with depression, doctors begin with 150 mg once daily. After a few days, the dose usually steps up to 300 mg – either as a single dose in the morning or split into 150 mg twice a day. The split‑dose option helps avoid sleeplessness, a common complaint.

If you’re 18‑24 years old, the starting dose stays the same, but the total daily amount should not exceed 300 mg because younger adults are more sensitive to side effects. Some people need a lower maintenance dose, like 200 mg daily, if they experience jittery feelings or headaches.

Never jump straight to the maximum dose. Bupropion builds up in your system, so a gradual increase lets your body adjust and reduces the risk of seizures, which are rare but linked to high doses.

Adjusting Dose for Smoking Cessation

When bupropion is used to help quit smoking (the brand name Zyban), the schedule is a bit different. You start with 150 mg once a day for three days. On day four, the dose goes up to 150 mg twice a day.

The goal is to keep the total at 300 mg daily until you’re smoke‑free. Some doctors keep the dose for 7‑12 weeks, then taper down to 150 mg once a day for a few weeks before stopping.

If you have liver or kidney problems, the doctor may lower the dose to 150 mg twice a day for the whole course. Always follow their guidance because the drug is cleared slower in those conditions.

Tips for Safe Use

Take bupropion with food if it upsets your stomach, but avoid a high‑fat meal right before bed – it can keep you awake. Set a reminder on your phone so you don’t miss a dose; consistency is key for the medication to work.

If you miss a dose, take it as soon as you remember, unless it’s close to your next scheduled dose. In that case, skip the missed one – don’t double up.

Watch for side effects like dry mouth, headache, or mild dizziness. Most fade after a week. If you notice any strange thoughts, rapid heartbeat, or severe rash, call your doctor immediately.

Finally, store bupropion at room temperature, away from moisture and heat. Keep it out of reach of children – accidental ingestion can be dangerous.

Getting the dosage right is a partnership between you and your doctor. Talk openly about how you feel, and let them know if you need adjustments. With the right plan, bupropion can help you feel better and stay smoke‑free.